The magnitude in the pharmacological influence of a compound is decided by three aspects: (i) affinity with the molecular goal, (ii) intrinsic exercise, and (iii) concentration with the target internet site. The affinities to the CB1 receptor of a range of naturally happening and synthetic psychoactive and non-psychoactive cannabinoids is described in Desk 2. The desk just isn't meant to record each individual compound or every published report of CB1 and CB2 receptor affinities; somewhat it is intended for being adequately comprehensive As an example the various classes plus the spread of Ki values that have been noted For lots of of these compounds. Ki values in the 10-100nM vary are frequently regarded as to signify reasonable receptor affinity. The outcomes present that Δnine-THC and another naturally happening psychoactive cannabinoids, i.e., Δ8-THC, cannabinol (CBN) and Δ9-Tetrahydrocannabivarin (THCV), are reasonably potent CB1 ligands and with very similar Ki values for CB1 and CB2 receptors, these compounds also are non-selective.

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